Meditating on psychedelics. A randomized placebo-controlled study of DMT and harmine in a mindfulness retreat
Background: In recent years, both meditation and psychedelics have attracted rapidly increasing scientific interest. While the current state of eviden…
A Brief Review on the Potential of Psychedelics for Treating Alzheimer’s Disease and Related Depression
Alzheimer’s disease (AD), the most common form of senile dementia, is poised to place an even greater societal and healthcare burden as the population…
The Potential Role of Serotonergic Hallucinogens in Depression Treatment
Due to an increasing number of depression diagnoses and limited effective treatments, researchers continue to explore novel therapeutic strategies for…
Psychedelics and Neuroplasticity: A Systematic Review Unraveling the Biological Underpinnings of Psychedelics
Clinical studies suggest the therapeutic potential of psychedelics, including ayahuasca, DMT, psilocybin, and LSD, in stress-related disorders. These …
Lysergic Acid Diethylamide, Psilocybin and Dimethyltryptamine in Depression Treatment: A Systematic Review
Despite many different kinds of substances available for depression treatment, depression itself still appears to be a clinical challenge. Recently, f…
Seeking the Psilocybiome: Psychedelics meet the microbiota-gut-brain axis
Moving towards a systems psychiatry paradigm embraces the inherent complex interactions across all levels from micro to macro and necessitates an inte…
Cardiovascular safety of psychedelic medicine: current status and future directions
Psychedelics are powerful psychoactive substances that alter perception and mood processes. Their effectiveness in the treatment of psychiatric diseas…
Sustained effects of single doses of classical psychedelics in humans
The serotonergic classical psychedelics include compounds that primarily activate the brain’s serotonin 2 A receptor (5-HT2AR), such as LSD, psilocybi…
A Single Dose of 5-MeO-DMT Stimulates Cell Proliferation, Neuronal Survivability, Morphological and Functional Changes in Adult Mice Ventral Dentate Gyrus
Abstract
The subgranular zone (SGZ) of dentate gyrus (DG) is one of the few regions in which neurogenesis is maintained throughout adulthood. It is be…
Chronic, Intermittent Microdoses of the Psychedelic N,N-Dimethyltryptamine (DMT) Produce Positive Effects on Mood and Anxiety in Rodents
Rationale
Drugs capable of ameliorating symptoms of depression and anxiety while also improving cognitive function and sociability are highly desirabl…