Application of Ketamine in Pain Management and the Underlying Mechanism
Since ketamine was approved by the FDA as an intravenous anesthetic, it has been in clinical use for more than 50 years. Apart from its anesthetic eff…
Predicting outcome with Intranasal Esketamine treatment: A machine-learning, three-month study in Treatment-Resistant Depression (ESK-LEARNING)
Treatment-resistant depression (TRD) represents a severe clinical condition with high social and economic costs. Esketamine Nasal Spray (ESK-NS) has r…
Ketamine in Trauma: A Literature Review and Administration Guidelines
Ketamine is a phencyclidine (PCP) derivative, which primarily acts as a noncompetitive N-methyl-D-aspartate (NMDA) receptor antagonist. Ketamine serve…
A pilot randomized controlled trial of ketamine in Borderline Personality Disorder
This study is the first randomized controlled trial to test the effects of ketamine in Borderline Personality Disorder (BPD). BPD remains undertreated…
The potential of ketamine for posttraumatic stress disorder: a review of clinical evidence
Posttraumatic stress disorder (PTSD) is a devastating condition, for which there are few pharmacological agents, often with a delayed onset of action …
Ketamine reduces the neural distinction between self- and other-produced affective touch – a double-blind placebo-controlled study
A coherent sense of self is crucial for social functioning and mental health. The N-methyl-D-aspartate antagonist ketamine induces short-term dissocia…
Ketamine and psychotherapy for the treatment of psychiatric disorders: systematic review
Background
Ketamine is an effective short-term treatment for a range of psychiatric disorders. A key question is whether the addition of psychotherapy…
Ketamine Treatment for Alcohol Use Disorder: A Systematic Review
Alcohol use disorder (AUD) is a chronic, recurrent condition that demonstrates significant heterogeneity in treatment response to first-line agents. K…
The effects of ketamine on symptoms of depression and anxiety in real-world care settings: A retrospective controlled analysis
Introduction
Ketamine intravenous therapy (KIT) appears effective for treating depression in controlled trials testing a short series of infusions. A …
Depression, Estrogens, and Neuroinflammation: A Preclinical Review of Ketamine Treatment for Mood Disorders in Women
Ketamine has been shown to acutely and rapidly ameliorate depression symptoms and suicidality. Given that women suffer from major depression at twice …