Rapid resolution of suicidal ideation after a single infusion of an N-methyl-D-aspartate antagonist in patients with treatment-resistant major depressive disorder
Method: Thirty-three subjects with DSM-IV-diagnosed MDD received a single open-label infusion of ketamine (0.5 mg/kg) and were rated at baseline and a…
A Single Ketamine Infusion Combined With Motivational Enhancement Therapy for Alcohol Use Disorder: A Randomized Midazolam-Controlled Pilot Trial
Methods: Participants were randomly assigned to a 52-minute intravenous administration of ketamine (0.71 mg/kg, N=17) or the active control midazolam …
A Randomized Controlled Trial of Repeated Ketamine Administration for Chronic Posttraumatic Stress Disorder
Rationale
Posttraumatic stress disorder (PTSD) is a chronic and disabling disorder, for which available pharmacotherapies have limited efficacy. The a…
Ketamine for acute suicidal ideation. An emergency department intervention: A randomized, double-blind, placebo-controlled, proof-of-concept trial
Rationale
Depressed patients presenting to emergency departments with acute suicidal ideation are a major public health concern. Ketamine, a rapidly a…
The effect of ketamine on preventing postpartum depression
Postpartum depression is a common disabling psychosocial disorder that could have adverse effects on the life of the mother, infant, and family. The p…
Efficacy of Intravenous Ketamine in Adolescent Treatment-Resistant Depression: A Randomized Midazolam-Controlled Trial
Objective
Adolescent depression is prevalent and is associated with significant morbidity and mortality. Although intravenous ketamine has shown effic…
Strategies to Prolong Ketamine’s Efficacy in Adults with Treatment-Resistant Depression
Introduction
Ketamine treatment is capable of significant and rapid symptom improvement in adults with treatment-resistant depression (TRD). A limitat…
Efficacy of ketamine and esketamine on functional outcomes in treatment-resistant depression: A systematic review
Background
In recent years, ketamine and esketamine treatment have demonstrated rapid antidepressant effects in adults with treatment-resistant depres…
Pharmacodynamic interactions between ketamine and psychiatric medications used in the treatment of depression: a systematic review
Background
The use of ketamine for depression has increased rapidly in the past decades. Ketamine is often prescribed as add-on to other drugs used in…
Age affects temporal response, but not durability, to serial ketamine infusions for treatment refractory depression
Rationale
Ketamine is a novel, rapid-acting antidepressant for treatment refractory depression (TRD); however, clinical durability is poor and treatme…