Rapid and sustained symptom reduction following psilocybin treatment for anxiety and depression in patients with life-threatening cancer: a randomized controlled trial.
Methods:
In this double-blind, placebo-controlled, crossover trial, 29 patients with cancer-related anxiety and depression were randomly assigned and…
Lysergic acid diethylamide (LSD) promotes social behavior through mTORC1 in the excitatory neurotransmission
Abstract
Clinical studies have reported that the psychedelic lysergic acid diethylamide (LSD) enhances empathy and social behavior (SB) in humans, but…
Lysergic Acid Diethylamide Induces Increased Signalling Entropy in Rats’ Prefrontal Cortex
Psychedelic drugs are gaining attention from the scientific community as potential new compounds for the treatment of psychiatric diseases such as moo…
Effect of LSD and music on the time-varying brain dynamics
Psychedelics are getting closer to being widely used in clinical treatment. Music is known as a key element of psychedelic-assisted therapy due to its…
Lysergic acid diethylamide-assisted therapy in patients with anxiety with and without a life-threatening illness: A randomized, double-blind, placebo-controlled Phase II study
Background
This study aimed to investigate the efficacy and safety of lysergic acid diethylamide (LSD)-assisted therapy in patients who suffered from …
Low doses of lysergic acid diethylamide (LSD) increase reward-related brain activity
Renewed interest in classic psychedelics as treatments for psychiatric disorders warrants a deeper understanding of their neural mechanisms. Single, h…
A non-hallucinogenic LSD analog with therapeutic potential for mood disorders
Hallucinations limit widespread therapeutic use of psychedelics as rapidly acting antidepressants. Here we profiled the non-hallucinogenic lysergic ac…
Acute mood-elevating properties of microdosed LSD in healthy volunteers: a home-administered randomised controlled trial
Background
Microdosing psychedelic drugs is a widespread social phenomenon with diverse claimed benefits to mood and cognition. Randomised controlled …
Dose-response relationships of LSD-induced subjective experiences in humans
Lysergic acid diethylamide (LSD) is a potent classic serotonergic psychedelic, which facilitates a variety of altered states of consciousness. Here we…
Sustained effects of single doses of classical psychedelics in humans
The serotonergic classical psychedelics include compounds that primarily activate the brain’s serotonin 2 A receptor (5-HT2AR), such as LSD, psilocybi…