Effects of discontinuation of serotonergic antidepressants prior to psilocybin therapy versus escitalopram for major depression
Background: There is growing evidence for the therapeutic effects of the psychedelic drug psilocybin for major depression. However, due to the lack of…
Catalyst for change: Psilocybin’s antidepressant mechanisms—A systematic review
Background: Recent clinical trials suggest promising antidepressant effects of psilocybin, despite methodological challenges. While various studies ha…
Psilocybin-assisted psychotherapy for Parkinson’s disease without depression: A case-report
Background: Psychedelic assisted psychotherapy (PAP) can improve treatment-resistant depression. Its usefulness in Parkinson’s disease (PD) is unknown…
Suicide of a patient shortly after psilocybin-assisted psychedelic therapy: A case report
Highlights:
- A 60-year-old man with recurrent depression and history of delusions died after psilocybin-assisted therapy.
Psychedelic treatment for anorexia nervosa: A first-hand view of how psilocybin treatment did and did not help
Anorexia nervosa (AN) is a psychiatric illness with high mortality rates and limited treatment outcomes. Psilocybin treatment (PT) has shown promise f…
Preliminary Evidence of Sleep Improvements Following Psilocybin Administration, and their Involvement in Antidepressant Therapeutic Action
Purpose of the study: Psilocybin is a rapidly-emerging treatment for depression, yet its impact on sleep is not well understood. We sought to explore …
Investigating the therapeutic efficacy of psilocybin in advanced cancer patients: A comprehensive review and meta-analysis
Background: Psilocybin, a naturally occurring psychedelic compound found in certain species of mushrooms, is known for its effects on anxiety and depr…
Effect of psilocybin versus escitalopram on depression symptom severity in patients with moderate-to-severe major depressive disorder: observational 6-month follow-up of a phase 2, double-blind, randomised, controlled trial
Background: Psilocybin therapy (PT) produces rapid and persistent antidepressant effects in major depressive disorder (MDD). However, the long-term ef…
Change in occupational burnout measures in emergency medical service workers after a psychedelic experience induced by a single self-administered dose of psilocybin mushrooms
Background and Aims: This naturalistic mixed methods field study, aimed to assess the potential of a psilocybin induced experience, to help Emergency …
Psilocybin and the glutamatergic pathway: implications for the treatment of neuropsychiatric diseases
In recent decades, psilocybin has gained attention as a potential drug for several mental disorders. Clinical and preclinical studies have provided ev…