The impact of antidepressant discontinuation prior to treatment with psilocybin for treatment-resistant depression
It has been suggested that the recent use and discontinuation of antidepressant drugs compromises the action of psilocybin. As evidence is only availa…
Preliminary safety and effectiveness of psilocybin-assisted therapy in adults with fibromyalgia: An open-label, pilot clinical trial
Fibromyalgia (FM) is the prototypical nociplastic pain condition, characterized by widespread pain and issues with cognition, mood, and sleep. Current…
Direct comparison of the acute effects of lysergic acid diethylamide and psilocybin in a double-blind placebo-controlled study in healthy subjects
Growing interest has been seen in using lysergic acid diethylamide (LSD) and psilocybin in psychiatric research and therapy. However, no modern studie…
Are psychedelics the answer to chronic pain: A review of current literature
Aims
We aim to provide an evidence-based overview of the use of psychedelics in chronic pain, specifically LSD and psilocybin.
Content
Chronic pain i…
Psychedelics and Neuroplasticity: A Systematic Review Unraveling the Biological Underpinnings of Psychedelics
Clinical studies suggest the therapeutic potential of psychedelics, including ayahuasca, DMT, psilocybin, and LSD, in stress-related disorders. These …
Lysergic Acid Diethylamide, Psilocybin and Dimethyltryptamine in Depression Treatment: A Systematic Review
Despite many different kinds of substances available for depression treatment, depression itself still appears to be a clinical challenge. Recently, f…
Seeking the Psilocybiome: Psychedelics meet the microbiota-gut-brain axis
Moving towards a systems psychiatry paradigm embraces the inherent complex interactions across all levels from micro to macro and necessitates an inte…
A Brief Review on the Potential of Psychedelics for Treating Alzheimer’s Disease and Related Depression
Alzheimer’s disease (AD), the most common form of senile dementia, is poised to place an even greater societal and healthcare burden as the population…
The Potential Role of Serotonergic Hallucinogens in Depression Treatment
Due to an increasing number of depression diagnoses and limited effective treatments, researchers continue to explore novel therapeutic strategies for…
Is microdosing a placebo? A rapid review of low-dose LSD and psilocybin research
Some recent research and commentary have suggested that most or all the effects reported by people who microdose psychedelics may be explained by expe…