Psilocybin in pharmacotherapy of obsessive-compulsive disorder
Obsessive-compulsive disorder (OCD) is a chronic mental disease that affects approximately 2% of the population. Obsessions and compulsions are troubl…
Single-dose psilocybin-assisted therapy in major depressive disorder: A placebo-controlled, double-blind, randomised clinical trial
Background
Psilocybin has been suggested as a novel, rapid-acting treatment for depression. Two consecutive doses have been shown to markedly decrease…
Adults who microdose psychedelics report health related motivations and lower levels of anxiety and depression compared to non-microdosers
The use of psychedelic substances at sub-sensorium ‘microdoses’, has gained popular academic interest for reported positive effects on wellness and co…
Pharmacokinetics and Pharmacodynamics of Oral Psilocybin Administration in Healthy Participants
Psilocybin is being investigated as a potential treatment for psychiatric and neurological disorders. Only a few studies have evaluated the pharmacoki…
Single-dose psilocybin for a treatment-resistant episode of major depression: Impact on patient-reported depression severity, anxiety, function, and quality of life
Background
COMP360 is a proprietary, synthetic formulation of psilocybin being developed for treatment-resistant depression (TRD), a burdensome, life-…
Optimizing outcomes in psilocybin therapy: Considerations in participant evaluation and preparation
Recent studies have demonstrated the promise of psilocybin therapies in creating positive changes for those with poor mental health across multiple di…
Acute psilocybin enhances cognitive flexibility in rats
Psilocybin has been shown to improve symptoms of depression and anxiety when combined with psychotherapy or other clinician-guided interventions. To u…
Psychotherapy with Psilocybin for Depression: Systematic Review
Depression is a common mental health issue that affects 280 million people in the world with a high mortality rate, as well as being a leading cause o…
Psilocybin in Palliative Care: An Update
Purpose of Review
This review article summarizes clinically and socially relevant developments over the past five years in the therapeutic use of the …
Case report: Prolonged amelioration of mild red-green color vision deficiency following psilocybin mushroom use
Background
Recent survey data indicate that some people report long-term improvement in color vision deficiency (CVD), also known as color blindness, …