The development of psilocybin therapy for treatment-resistant depression: an update
Psilocybin is a classic psychedelic drug that has attracted increasing research interest over the past 10 years as a possible treatment for mood, anxi…
Psilocybin for treatment resistant depression in patients taking a concomitant SSRI medication
Psilocybin is being investigated as a treatment in adults with treatment-resistant depression (TRD). Withdrawal from serotonergic antidepressant drugs…
Assessing the risk of symptom worsening in psilocybin-assisted therapy for depression: A systematic review and individual participant data meta-analysis
We conducted a meta-analysis using individual participant data from three, two-dose psilocybin trials for depression (N = 102) with the aim of assessi…
Psilocybin therapy for females with anorexia nervosa: a phase 1, open-label feasibility study
Anorexia nervosa (AN) is a deadly illness with no proven treatments to reverse core symptoms and no medications approved by the US Food and Drug Admin…
Single-Dose Psilocybin Treatment for Major Depressive Disorder: A Randomized Clinical Trial
Importance: Psilocybin shows promise as a treatment for major depressive disorder (MDD).
Objective: To evaluate the magnitude, timing, and dur…
Effects of psilocybin versus escitalopram on rumination and thought suppression in depression
Background
Major depressive disorder is often associated with maladaptive coping strategies, including rumination and thought suppression.
Aims
To as…
Psilocybin-assisted therapy for depression: A systematic review and dose-response meta-analysis of human studies
Psilocybin is increasingly studied for its antidepressant effect, but its optimal dosage for depression remains unclear. We conducted a systematic rev…
Body mass index (BMI) does not predict responses to psilocybin
Background
Psilocybin is a serotonin type 2A (5-HT2A) receptor agonist and naturally occurring psychedelic. 5-HT2A receptor density is known to be ass…
Cardiovascular safety of psychedelic medicine: current status and future directions
Psychedelics are powerful psychoactive substances that alter perception and mood processes. Their effectiveness in the treatment of psychiatric diseas…
Psilocybin as a Treatment for Psychiatric Illness: A Meta-Analysis
Psilocybin is an emerging potential therapy for the treatment of psychiatric illnesses. Microdosing has been shown to result in an overall improvement…