Long-term Follow-up of Psilocybin-facilitated Smoking Cessation
Background
A recent open-label pilot study (N=15) found that two to three moderate to high doses (20 and 30 mg/70 kg) of the serotonin 2A receptor ago…
Persisting decreases in state and trait anxiety post-psilocybin: A naturalistic, observational study among retreat attendees
Anxiety disorders are the most common type of psychiatric disorders among Western countries. Evidence-based treatment modalities including pharmacolog…
Psilocybin with psychological support for treatment-resistant depression: six-month follow-up
Methods: Twenty patients (six females) with (mostly) severe, unipolar, treatment-resistant major depression received two oral doses of psilocybin (10 …
Unraveling the Mysteries of Mental Illness With Psilocybin
Current medications have not been effective in reducing the prevalence of mental illness worldwide. The prevalence of illnesses such as treatment-resi…
Exploratory Controlled Study of the Migraine-Suppressing Effects of Psilocybin
In an exploratory double-blind, placebo-controlled, cross-over study, adults with migraine received oral placebo and psilocybin (0.143 mg/kg) in 2 tes…
Psilocybin for Trauma-Related Disorders
Posttraumatic stress disorder (PTSD) is a debilitating, chronic disorder and efficacy rates of current PTSD treatments are underwhelming. There is a c…
Effects of Psilocybin-Assisted Therapy on Major Depressive Disorder
Rationale
Major depressive disorder (MDD) is a substantial public health burden, but current treatments have limited effectiveness and adherence. Rece…
Percentage of Heavy Drinking Days Following Psilocybin-Assisted Psychotherapy vs Placebo in the Treatment of Adult Patients With Alcohol Use Disorder
Importance
Although classic psychedelic medications have shown promise in the treatment of alcohol use disorder (AUD), the efficacy of psilocybin re…
Optimal dosing for psilocybin pharmacotherapy: Considering weight-adjusted and fixed dosing approaches
Rationale
Growing evidence suggests psilocybin, a naturally occurring psychedelic, is a safe and promising pharmacotherapy for treatment of mood and s…
Trial of Psilocybin versus Escitalopram for Depression
Background
Psilocybin may have antidepressant properties, but direct comparisons between psilocybin and established treatments for depression are lack…