Effects of Psilocybin-Assisted Therapy on Major Depressive Disorder: A Randomized Clinical Trial
Background
Major depressive disorder (MDD) is a substantial public health burden, but current treatments have limited effectiveness and adherence. Rec…
Drug-drug interactions between psychiatric medications and MDMA or psilocybin: a systematic review
Rationale & objectives
± 3,4-Methylenedioxymethamphetamine (MDMA) and psilocybin are currently moving through the US Food and Drug Administration’s p…
Adverse events in clinical treatments with serotonergic psychedelics and MDMA: A mixed-methods systematic review
Introduction
Small-scale clinical studies with psychedelic drugs have shown promising results for the treatment of several mental disorders. Before ps…
Co-use of MDMA with psilocybin/LSD may buffer against challenging experiences and enhance positive experiences
Psilocybin and lysergic acid diethylamide (LSD) experiences can range from very positive to highly challenging (e.g., fear, grief, and paranoia). Thes…
Sustained effects of single doses of classical psychedelics in humans
The serotonergic classical psychedelics include compounds that primarily activate the brain’s serotonin 2 A receptor (5-HT2AR), such as LSD, psilocybi…
Comparative acute effects of mescaline, lysergic acid diethylamide, and psilocybin in a randomized, double-blind, placebo-controlled cross-over study in healthy participants
Mescaline, lysergic acid diethylamide (LSD), and psilocybin are classic serotonergic psychedelics. A valid, direct comparison of the effects of these …
The therapeutic potential of microdosing psychedelics in depression
Rationale
Microdosing psychedelics is the repeated use of small doses of, for example, lysergic acid diethylamide (LSD) and psilocybin, typically for …
The Use of Classic Hallucinogens/Psychedelics in a Therapeutic Context: Healthcare Policy Opportunities and Challenges
Psychedelics or serotonergic hallucinogens are a group of substances that share the agonism of serotonergic 5-HT2A receptors as their main mechanism o…
LSD and psilocybin for chronic nociplastic pain: A narrative review of the literature supporting the use of classic psychedelic agents in chronic pain
Healthcare providers face the challenging task of managing patients who suffer from chronic nociplastic pain conditions. Pain is a …
Psilocybin for Obsessive-Compulsive Disorder (OCD) with Sorcha O’Connor, PhD(c)
In this episode, Sorcha O’Connor, PhD(c) joins to discuss the research into the use of psilocybin to address obsessive-compulsive disorder (OCD). Sorc…